Making Fiends, our Number 2 pick for 2006, is an amazing animation series by Amy Winfrey where a little blue girl named Charlotte moves from Vermont to the torment of a little green girl named Vendetta who lives to make fiends out of potions. Sure, it may seem like the standard good versus evil theme, but Making Fiends is so over the top (Vendetta has a terrific Eastern European accent) that it is hilarious, in a sweetly deranged sort of way. What’s not to love?